A novel peptide from the skin of amp Source Nat Prod Res SO 2020 Jan 21 1 5

ABSTRACT
In clinical trials, the healing of wounds remains a substantial
physiological and financial incumbrance on patients. Therefore,
the development of new drugs that can accelerate wound healing
is vital. Based on genomic methods, we identified a new peptide
(RL-RL10) with the amino acid sequence ‘RLFKCWKKDS’ from the
skin of an amphibian frog species (Rana limnocharis). RL-RL10 promoted
wound healing of human keratinocytes (HaCaT) in a concentration-
dependent manner. RL-RL10 also had an effect on the
migration and proliferation of HaCaT cells and promoted healing
of a full-thickness wound in mice in a dose-dependent manner. In
conclusion, we discovered RL-RL10 that promoted healing activity
of cellular and animal wounds, thus providing a new peptide
template for the development of novel wound-repairing drugs.